Abstract: Human health depends on the health of our environment. Dramatic changes in our environment and ecological systems are affecting the quality of our air, water, and food and the resilience of communities around the world – particularly, marginalized and low-income populations. As climate change, pollution, deforestation, and multiple other environmental challenges grow in urgency, we are faced with shifting patterns of disease, and new threats to human health, well-being, and security. In this era of rapid change, the role of physicians and other health professionals is evolving. The future of medicine require physicians capable of detecting sentinel cases of disease due to environmental factors, systems thinking, urgent action, and interdisciplinary approaches to healthcare and stewardship. The “Medicine for a Changing Planet” curriculum will be based upon a set of approximately 10 competency-driven, interactive clinical cases that demonstrate the health impacts of global environmental challenges and provide concrete skills to address these challenges in the patient care setting.